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The SF 49ers and Tennessee Titans will take center stage on TNF at 8:20 EST. The 49ers come into this game favored on the road but they tend to thrive in this situation going (8-2 ATS) as a road favorite of 7 points or less over the L3 years and QB J. Garoppolo is (15-7 ATS) vs defenses that allow 19 to 25 points/game. The 49ers will be missing a few linebackers tonight along with RB E. Mitchell but the Titans are missing their starting LG, LT and a couple of defensive guys. NFC road teams playing @ AFC opponents this year are (23-12 ATS), San Francisco is also (5-1 SU/ATS) in their L6 games.
Pick: SF 49ERS -3